Postdoctoral Positions
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Other Positions
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New Spin-off positions
This is a unique opportunity to join a private, biology-driven and preclinical-stage company, newly incorporated as a spin-off of the Ludwig Institute for Cancer Research and the Université catholique de Louvain.
This spin-off will leverage tumor immunology expertise from the Ludwig Institute to focus on discovery and development of first-in-class small molecule drugs that stimulate the immune system’s ability to detect and eliminate cancers. It will validate their therapeutic use in preclinical and clinical models to improve the efficacy of cancer treatments, with an initial focus on the improvement of therapeutic cancer vaccines.
The company will offer a stimulating challenge for talented scientists and drug developers with a strong entrepreneurial spirit.
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Director - Medicinal Chemistry (full-time position)
Role
This position will provide scientific leadership and drug discovery/medicinal chemistry expertise for lead discovery and optimization projects. Reporting to the CEO, the candidate will develop and take ownership of various strategic initiatives for the drug discovery programs. The candidate must have proven track of effective project leadership within cross-functional teams, including effective management and decision making, as well as strong communications skills. Must be able to examine, prioritize and give credible scientific input on new concepts, molecular designs and other ideas coming from CROs, partners and consultants. In addition he/she is expected to develop and maintain strong awareness of external scientific and technological advances in the field of drug discovery. The candidate will develop contacts with thought leaders, professional organizations, and institutions and will represent company’s chemistry externally.Key Tasks & Responsibilities
- Ensure that projects are accomplished on time and within budget
- Manage outsourced chemistry and collaboration with the Ludwig Institute for Cancer Research
- Provide scientific expertise and leadership. He/She should be able to integrate multiple complex data sets, analyze/interpret them and propose solutions
- Communicate very effectively in written and oral form. He/She should be able to write high-quality complete scientific reports, publications and have excellent presentation and public speaking skills. The candidate should be able to critique scientific presentations/reports in professional and credible manner. Represent and increase the reputation of the company in external scientific meetings. Communicate and collaborate effectively with CROs, consultants and other external organizations
- Participate actively in project meetings and other collaborative committee meetings, and share openly his/her scientific ideas, and technology knowledge. Assume responsibility for executing strategic initiatives within the function;
- Demonstrate ability to contribute on various aspects outside own scientific area, and is able to collaborate with stakeholders from all relevant functions. Keep up-to-date in the literature related to the field.
Qualifications
Education
- PhD degree and >5 years of post-doc related industrial drug discovery experience
Professional Skills & Experience
- Must have proven scientific leadership proficiency in medicinal chemistry
- Good publication record in peer reviewed journals often as first author
- Leadership and mentorship abilities with significant experience in managing CROs
- Successful drug discovery record, with compounds that have advanced in clinical trials
- Some insight in molecular modeling.
Personal Skills & Competencies
- Management and leadership experience, detail-oriented, with excellent record-keeping, project and budget management skills
- Excellent oral and written communication skills. Able to effectively present scientific data and concepts to international standards
- Strong team spirit and excellent interpersonal skills
- Ability to think strategically.
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Associate Director - Tumor Immunology (full-time position)
Role
The purpose of this position is to lead company’s research efforts in small molecule immunomodulator discovery and development. Reporting to the CSO, the candidate will develop and take ownership of various strategic initiatives for the drug discovery programs. The candidate must have a proven track of effective project leadership within cross-functional teams, including effective management and decision making, as well as strong communications skills. Hire, direct, and develop qualified scientific staff and ensure that projects are accomplished on time and within budget. Must be able to manage the performance of his/her group effectively resulting in highest productivity, creativity and efficiency. Must be able to examine, prioritize and give credible scientific input on new concepts and other ideas coming from CROs, partners and consultants. In addition, he/she is expected to develop and maintain strong awareness of external scientific and technological advances in the field of drug discovery related to tumor immunology and immunomodulation. The candidate will develop contacts with thought leaders, professional organizations, and institutions and will represent company R&D externally.
Key Tasks & Responsibilities
- Lead a team focused on the discovery, development and preclinical validation of innovative immunomodulators for cancer therapy in ex vivo and in vivo models
- Define the role and mechanism of action of these immunomodulators
- Ensure that projects are accomplished on time and within budget
- Take measures to create a group environment that allows innovation and ensures high productivity and laboratory safety
- Provide scientific expertise and leadership. The candidate should be able to integrate multiple complex data sets, analyze/interpret them and propose solutions
- Implement collaboration with the Ludwig Institute for Cancer Research
- Communicate very effectively in written and oral form. He/She should be able to write high-quality complete scientific reports, publications and has excellent presentation and public speaking skills. He/She should also be able to critique scientific presentations/reports in professional and credible manner. Represent and enhance the reputation of the company in external scientific meetings. Communicate and collaborate effectively with CROs, consultants and other external organizations
- Participate actively in project meetings and other collaborative committee meetings, and share openly his/her scientific ideas, and technology knowledge. Assume responsibility for executing strategic initiatives within the function
- Demonstrate ability to contribute on various aspects outside own scientific area, and collaborate with stakeholders from all relevant functions. Keep up-to-date in the literature related to his/her field. Act as an expert resource in his/her scientific field and in related disciplines
- Initiate novel, target related biological research in tumor immunology, as well as the development of biomarkers for human clinical trials for these agents.
Qualification
Education
- Ph.D. or M.D. in immunology or a closely related field and >5 years of post-doc related industrial drug discovery experience
Professional Skills & Experience
- Must have proven scientific leadership proficiency in tumor immunology
- Good publication record in peer-reviewed journals often as first author
- Leadership and mentorship abilities with significant experience in managing multiple direct reports
- Successful drug discovery record, with compounds that have advanced in clinical trials
- A strong background in cellular and/or tumor immunology. Familiarity with tumor models and mechanisms of anti-tumor responses with strength in the analysis of the activity of lymphocyte/monocyte subsets in anti-tumor immunity is highly desirable.
Personal Skills & Competencies
- Management and leadership experience, detail-oriented, with excellent record-keeping, project and budget management skills
- Excellent oral and written communication skills. Able to effectively present scientific data and concepts to international standards
- Strong team spirit and excellent interpersonal skills
- Ability to think strategically.
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3 Research Associates - Discovery Immunology (full-time positions)
Role
The purpose of these positions is to develop the company’s research efforts in small molecule immunomodulators discovery and development. The responsibilities will include assay development and implementation to enable the progression of new small molecule therapeutics. The position will also involve the study of immune system-tumor interaction by development of ex vivo and in vivo models and evaluation of the immunomodulators using these models.
Key Tasks & Responsibilities
- Be part of a team focused on the discovery, development and preclinical validation of innovative immunomodulators for cancer therapy in murine models
- Ensure high productivity and laboratory safety
- Communicate very effectively in written and oral form
- Participate actively in project meetings and other collaborative committee meetings, and share openly his/her scientific ideas, and technology knowledge. Assume responsibility for executing strategic initiatives within the function
- Contribute to various aspects outside own scientific area, and collaborate with stakeholders from all relevant functions.
Qualification
Education
- Bachelor/Master in science or equivalent in immunology, biochemistry or a closely related field, and >3 years of experience in the biotech/pharmaceutical industry or in a similar academic position are required. Years of experience required can vary depending on the qualifications of the candidate.
Professional Skills & Experience
- A strong background in cellular and/or tumor immunology
- Familiarity with tumor models and mechanisms of anti-tumor responses with strength in the analysis of the activity of inflammatory cell subsets in anti-tumor immunity
- Extensive experience with recombinant cell line development and use
- Strong background and experience in immunology-related technologies including flow cytometry, multiplex immunoassays, immune cell isolation and primary lymphocyte cell culture
- Knowledge of signaling assays, Western blotting, gene transfer, quantitative RT-PCR and automated assay technologies
- Experience with animal models
- Familiarity with tumor models and mechanisms of anti-tumor responses with strength in the analysis of the activity of lymphocyte/monocyte subsets in anti-tumor immunity.
Personal Skills & Competencies
- Independence to design, execute and interpret experiments
- Experienced, rigorous, detail-oriented, autonomous and highly motivated
- Excellent oral and written communication skills
- Strong team spirit and excellent interpersonal skills.
Primary Location: Gosselies, Belgium
The company offers offers competitive compensation salary and benefits commensurate with experience level, as well as an opportunity to work within modern and well-equipped facilities. Employment is compatible with a choice of lifestyles either in the surrounding, rural communities, or the cosmopolitan, European capital of Brussels within commuting distance.
Only selected candidates will be contacted.
Please send your resume and motivation letter to Julie Klein
Ludwig Institute for Cancer Research Ltd
Av. Hippocrate, 75 Bte B1.74.03
B - 1200 Brussels
BELGIUM
Julie.Klein@bru.licr.org
